产品说明
一般描述
Keratin 18/cytokeratin 18 (CK18) is a structural protein. It is present in single-layer epithelia. It is located on human chromosome 12q13.
The antibody DC-10 reacts with Cytokeratin 18 (45 kDa). Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues.
免疫原
Human breast carcinoma cell line PMC-42
应用
The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 5-10 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
生化/生理作用
Keratins help to maintain the structural integrity. They also control Fas‐mediated apoptosis and regulate cell size and protein synthesis. Keratin 18 plays a major role in the development of lung cancer. It acts as a therapeutic target for non-small cell lung cancer (NSCLC).
特点和优势
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外形
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | mouse |
| 偶联物 | FITC conjugate |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | DC-10, monoclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| 浓度 | 0.1 mg/mL |
| technique(s) | flow cytometry: suitable |
| 同位素/亚型 | IgG1 |
| NCBI登记号 | NM_000224.2 |
| UniProt登记号 | P05783 |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| Gene Information | human ... KRT18(3875) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
