产品说明
一般描述
PTEN induced kinase 1 (PINK1), a serine/threonine kinase localizes to mitochondria. It comprises an N-terminal mitochondrial targeting sequence, C-terminal kinase domain, and a transmembrane anchor region. The PINK1 gene is mapped to human chromosome 1p36.12.
免疫原
Fusion protein amino acids 112-496 (cytoplasmic C-terminus) of human PINK1. 82% identical to rat and 81% identical to mouse. >30% identity with DMPK.
生化/生理作用
PTEN induced kinase 1 (PINK1) participates in mitochondrial component biogenesis. It mediates the translation of mitochondrial respiratory chain subunits encoding nuclear mRNAs. The kinase domain region of PINK1 gene harbors most of the mutations. Mutations in the PINK1 gene are implicated in early-onset Parkinson′s disease (PD). The accumulation of PINK1 in dysfunctional mitochondria marks them for degradation. PINK1 is also implicated in the pathophysiology of cancer, diabetes, and pulmonary fibrosis.
特点和优势
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外形
PBS pH 7.4, 50% glycerol, 0.1% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | S4-15, monoclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen predicted mol wt 50 kDa |
| species reactivity | rat, human, mouse |
| 浓度 | 1 mg/mL |
| technique(s) | immunocytochemistry: suitable immunohistochemistry: suitable western blot: suitable |
| 同位素/亚型 | IgG1 |
| NCBI登记号 | NP_115785.1 |
| UniProt登记号 | Q9BXM7 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PINK1(65018) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
