产品说明
一般描述
p53 upregulated modulator of apoptosis (PUMA), commonly known as BCL2 (B-cell lymphoma 2) binding component 3 (BBC3) encodes a mitochondrial protein. BBC3 has BH3 (Bcl-2 Homology 3) domain. PUMA is expressed in all the tissues at a very low levels. In human chromosome, the gene BBC3 is localized on 19q13.32.
免疫原
Mouse monoclonal PUMA antibody was raised against a recombinant protein corresponding to amino acids 76 – 170 of human PUMA-alpha.
生化/生理作用
p53 upregulated modulator of apoptosis (PUMA) is upregulated by p53, by binding to its promoter, inducing apoptosis in tumor cells. PUMA binds to Bcl2 and Bcl-xL (B-cell lymphoma-extra large) through BH3 domain and inhibits the antiapoptotic activity. PUMA releases p53 bound to Bcl-xL, and promotes p53 mediated apoptosis. PUMA causes apoptosis in colorectal cancer, ovarian cancer, and colon cancer. PUMA can be used as a directed gene therapy for in various forms of arthritis.
特点和优势
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外形
Supplied in PBS with 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD04040564 |
| NACRES | NA.41 |
产品性质
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 2A8F6, monoclonal |
| 形式 | buffered aqueous solution |
| species reactivity | rat, human |
| technique(s) | indirect ELISA: suitable western blot: suitable |
| NCBI登记号 | Q9BXH1 |
| UniProt登记号 | Q9BXH1 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... BBC3(27113) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
