11-环丙基-5,11-二氢-4-甲基-6H-二吡啶基[3,2-b:2′,3′-e][1,4] 二氮杂- 6-酮

产品名称：

129618-40-2
Nevirapine
11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one
奈韦拉平
11-环丙基-5,11-二氢-4-甲基-6H-二吡啶基[3,2-b:2′,3′-e][1,4] 二氮杂- 6-酮

产品介绍：

产品说明

应用

Nevirapine has been used as non-nucleoside reverse transcriptase inhibitor in in vitro porcine endogenous retrovirus replication, primary hepatocytes and bone marrow dendritic cells (BMDCs).

包装

10, 50 mg in glass bottle

生化/生理作用

奈韦拉平是 HIV 逆转录酶(NNRTI)的变构非核苷抑制剂。奈韦拉平抑制野生型 RT 的 K_i 为 200 nM。
Nevirapine interacts with glycine 190 residue of human immuno deficiency virus (HIV-2) reverse transcriptase. It is an antiretroviral drug which increases bile synthesis and activates electron transport chain. Use of nevirapine leads to liver toxicity and is associated with Nevirapine hypersensitivity syndrome.

基本信息

经验(实验)分子式	C₁₅H₁₄N₄O
分子量	266.30
MDL编号	MFCD00866928
PubChem化学物质编号	329825155
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to tan
溶解性	DMSO: ≥22 mg/mL
储存温度	room temp
SMILES string	CC1=CC=NC2=C1NC(C(C=CC=N3)=C3N2C4CC4)=O
InChI	1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
InChI key	NQDJXKOVJZTUJA-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable