PA-824

产品名称：

187235-37-6
PA-824
(6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
PA 824
(6S)- 6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-Imidazo[2,1-b][1,3]oxazine
(S)-PA 824
Pretomanid

产品介绍：

产品说明

包装

10, 50 mg in glass bottle

生化/生理作用

PA-824 is an anti-tuberculosis drug.
PA-824 is a pro-drug that has an effect on both replicating and non-replicating Mycobacterium tuberculosis. It is activated by deazaflavin (cofactor F420)-dependent nitroreducase.
PA-824 is an anti-tuberculosis drug that exhibits multiple mechanism of action, including both cell wall inhibition and respiratory poisoning.

基本信息

经验(实验)分子式	C₁₄H₁₂F₃N₃O₅
分子量	359.26
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D -40 to -48°, c = 1 in methanol
颜色	white to brown
溶解性	DMSO: 5 mg/mL, clear (warmed)
储存温度	−20℃
InChI	1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1
InChI key	ZLHZLMOSPGACSZ-NSHDSACASA-N

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P280 - P304 + P340 + P312 - P305 + P351 + P338 - P337 + P313
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable