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PLK1 Polo Box Domain active human

品牌
Sigma-Aldrich
货号
SRP0360
规格纯度
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
参考价格
8365.25 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
PLK1 Polo Box Domain active human
Polo-like kinase 1
STPK13
产品介绍:

产品说明

一般描述

Human Plk1 polo box domain (GenBank Accession No. NM_005030), amino acids 367-end with N-terminal GST-tag, MW=53 kDa, expressed in an E. coli expression system.
Polo-like kinase 1 (PLK1) belongs to the PLK family. It comprises polo-box domain (PBD). PBD, in turn, contains polo boxes (PB1 and PB2) with a 6-stranded β sandwich and an α helix as structural elements. The PLK1 gene is mapped to human chromosome 16p12.2.

应用

PLK1 Polo Box Domain active human has been used in the in vitro binding assay with various synthetic peptides coupled to streptavidin beads. It has also been used in binding studies with fluorescein-labeled substrate peptide 5-carboxyfluorescein-GPMQSpTPLNG to test the effect of various inhibitors.

生化/生理作用

Polo-like kinase 1 (PLK1) is a mitotic kinase that mediates the regulation of various events in mitosis including chromosome segregation, cytokinesis, centrosome maturation, and separation. It activates cell division cycle 25 (CDC25) phosphatase which further regulates mitotic entry. Elevated expression of PLK1 is observed in many tumors.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in E. coli
测定≥90% (SDS-PAGE)
形式aqueous solution
分子量 53 kDa
包装pkg of 100 μg
储存条件avoid repeated freeze/thaw cycles
浓度2.9 mg/mL
NCBI登记号NM_005030
UniProt登记号P53350
运输dry ice
储存温度−70℃
Gene Informationhuman ... PLK1(5347)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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