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PRMT6 active human

品牌
Sigma-Aldrich
货号
SRP0389
规格纯度
recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
参考价格
8831.52 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
PRMT6 active human
HRMT1L6
protein arginine N-methyltransferase 6
Histone-arginine N-methyltransferase 6
产品介绍:

产品说明

一般描述

Protein arginine methyltransferase 6 (PRMT6) is a 41.9kDa protein with 375 amino acids. It is encoded by the gene mapped to human chromosome 1. It belongs to type I enzyme, which is a subclass of PRMT family. PRMT6 is localized exclusively in nucleus.
Human PRMT6 (GenBank Accession No. NM_018137), amino-acids 2-375 (end), with N-terminal His-tag, MW=43kDa, expressed in Escherichia coli.

应用

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

生化/生理作用

Protein arginine methyltransferase 6 (PRMT6) catalyze the formation of asymmetric ω-NG,NG -dimethylarginine residues. In addition, PRMT6 show automethylation activity, which is unique among the members of PRMT family. PRMT6 mediates cigarette smoke extract (CSE)-triggered apoptosis and inflammation via di-methylation H3 arginine 2 (H3R2me2a) in human umbilical vein endothelial cells (HUVECs). PRMT6 plays a crucial role in various physiological processes such as transcriptional regulation, DNA repair and human immunodeficiency virus pathogenesis. Upregulated expression of the enzyme might be favorable for tumor growth and progression. Overexpression of PRMT6 has been observed in various type of malignancies including breast, cervix, bladder, prostate and lung cancer.

外形

Formulated in 200 mM imidazole, 20% glycerol, and 3 mM DTT.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in E. coli
测定≥70% (SDS-PAGE)
形式aqueous solution
分子量 43 kDa
包装pkg of 20 μg
NCBI登记号NM_018137
UniProt登记号Q96LA8
运输dry ice
储存温度−70℃
Gene Informationhuman ... PRMT6(55170)

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H315 - H319 - H360D
预防措施声明P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
危险分类Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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