Rabbit anti-FOXO1a Antibody, Affinity Purified

产品说明

免疫原

The epitope recognized by PLA0084 maps to a region between residues 600 and the C-terminus (residue 652) of human Forkhead Box O1a using the numbering given in Swiss-Prot entry Q12778 (GeneID 2308).

外形

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

其他说明

Forkhead box protein 01A (FOXO1a) belongs to a large family of Forkhead proteins that possesses a winged-helix DNA-binding domain called Forkhead box (FOX). FOXO1 is a transcription factor that integrates cell signals to mediate metabolism, the cell cycle, DNA repair, and response to cellular stress. In response to insulin, FOXO1 is phosphorylated by Akt and excluded from the nucleus and subsequently degraded. Over-expressed cytoplasmic FOXO1 interacts with TSC2 to cause its degradation and subsequent activation of the mTOR pathway; while nuclear localization inhibits the mTOR pathway.

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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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