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RBP4 human

品牌
Sigma-Aldrich
货号
SRP6532
规格纯度
recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)
参考价格
4589.39 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
RBP4 human
Retinol Binding Protein 4
RBP
PRBP
Plasma retinol-binding protein
产品介绍:

产品说明

一般描述

Retinol binding protein 4 (RBP4) is a 21kDa secreted protein encoded by the gene mapped to human chromosome 10q23–q24. RBP4 belongs to the lipocalin family, involved in the migration of small hydrophobic molecules. RBP4 is majorly expressed in liver and adipose tissues.

生化/生理作用

Retinol binding protein 4 (RBP4) acts as a primary transporter of retinol (vitamin A) in blood. RBP4 might act as a potent biomarker for abdominal obesity. Aberration in the expression of RBP4 is associated with the pathogenesis of Type 2 diabetes mellitus (T2DM), obesity and insulin resistance. Overexpression of serum RBP4 increases the risk for carotid artery plaque formation and coronary heart disease (CHD) in Chinese population. Therefore, regulation of serum RBP4 level might be implicated in prevention, diagnosis, and CHD treatment. A recent study in non-obese subjects revealed that decreased expression of glucose transporter 4 (GLUT4) in adipose tissues results in an elevated serum RBP4 level and insulin resistance.

外形

0.5 mg/mL of 0.2 μm-filtered solution in PBS, pH 7.2.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in HEK 293 cells
测定≥90% (SDS-PAGE)
形式liquid
分子量monomer ~230 kDa (Human RBP4 aa 19-201 is fused at the N-terminus to a FLAG0174-tag.)
包装pkg of 10 μg
pkg of 50 μg
杂质<0.1 EU/μg endotoxin (LAL test)
UniProt登记号P02753
运输wet ice
储存温度−20℃
Gene Informationhuman ... RBP4(5950)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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