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RNA Polymerase II, C-terminal domain, GST tagged human

RNA聚合酶II,C端域,GST标记 人

品牌
Sigma-Aldrich
货号
SRP2120
规格纯度
recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
参考价格
5276.03 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
RNA Polymerase II, C-terminal domain, GST tagged human
hRPB220
POLRA
RPB1
RPO2
RPOL2
RNA聚合酶II,C端域,GST标记 人
产品介绍:

产品说明

生化/生理作用

The carboxy-terminal repeat domain (CTD) of the largest subunit of RNA pol II contains tandem repeats of a heptapeptide sequence Tyr-Ser-Pro-Thr-Ser-Pro-Ser which is highly conserved among eukaryotic organisms. There are two forms of RNA pol II in vivo: IIO, which is extensively phosphorylated at the CTD, and IIA, which is not phosphorylated. The IIA form preferentially enters the pre-initiation complex (PIC), whereas IIO is found in the elongation complex. The kinase activity of TFIIH can mediate CTD phosphorylation, although other kinases, including Cdc2, Ctk1, the Srb10-Srb11 kinase-cyclin pair, and P-TEFb, have also been implicated in CTD phosphorylation. A phosphatase responsible for the dephosphorylation of the CTD has also been identified. CTD phosphatase activity is regulated by TFIIB and TFIIF. The CTD has also been implicated in pre-mRNA processing, most likely functioning as a platform for the recruitment and assembly of factors involved in pre-mRNA processing.
The CTD works as a binding scaffold for nuclear factors through its phosphorylation. It is suggested to be also involved in chromatin structure modification, DNA damage/repair, protein degradation and synthesis, RNA degradation, snRNA (small nuclear RNA) modification, and snoRNP (small nucleolar ribonucleoprotein) biogenesis.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源human
重组expressed in E. coli
测定≥70% (SDS-PAGE)
形式frozen liquid
分子量 ~68.1 kDa
包装pkg of 10 μg
储存条件avoid repeated freeze/thaw cycles
颜色clear colorless
NCBI登记号NM_000937
UniProt登记号P24928
运输dry ice
储存温度−70℃
Gene Informationhuman ... POLR2A(5430)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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