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SERPINA8 human

品牌
Sigma-Aldrich
货号
SRP6261
规格纯度
recombinant, expressed in HEK 293 cells, ≥98% (SDS-PAGE)
参考价格
4688.81 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
SERPINA8 human
SERPINA8
Angiotensinogen
ANHU
AGT
产品介绍:

产品说明

一般描述

Serpin A8 also known as angiotensinogen (AGT) , is a member of the serpin family. It is an α-2-globulin that is expressed by the liver and secreted in plasma. As essential component of the renin-angiotensin system (RAS), Angiotensinogen is cleaved into three chains: Angiotensin-1 (Ang I), Angiotensin-2 (Ang II), and Angiotensin-3 (Ang III) in lowered blood pressure by the enzyme renin. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Angiotensin-3 stimulates aldosterone release. Defects in AGT are a cause of renal tubular dysgenesis (RTD).

外形

Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in HEK 293 cells
标签6-His tagged (N-terminus)
测定≥98% (SDS-PAGE)
形式lyophilized powder
分子量calculated mol wt 50.6 kDa
observed mol wt 55-60 kDa (DTT-reduced. Protein migrates due to glycosylation. Asp 34 is the predicted N-terminus.)
包装pkg of 10 μg
杂质<1 EU/μg endotoxin (LAL test)
UniProt登记号P01019
运输wet ice
储存温度−20℃
Gene Informationhuman ... AGT(183)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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