N-[(2E)-3,7-Dimethyl-2,6-octadienyl]-N′-tricyclo[3.3.1.13,7]dec-2-yl-1,2-ethanediamine

产品名称：

502487-67-4
SQ109
N-[(2E)-3,7-Dimethyl-2,6-octadienyl]-N′-tricyclo[3.3.1.13,7]dec-2-yl-1,2-ethanediamine
N-[(2E)-3,7-dimethyl-2,6-octadienyl]-NOE-tricyclo[3.3.1.13,7]dec-2-yl-1,2-ethanediamine
NSC 722041

产品介绍：

产品说明

一般描述

SQ109 is a 1,2-ethylenediamine, which is related to ethambutol.

应用

SQ109 has been used:

as an antitubercular agent to study its interactions with mycobacterial membrane proteins large 3 (MmpL3) binding pocket
as a positive control to determine the minimum inhibitory concentration (MIC) of ohmyungsamycins (OMS) A and B against Mycobacterium tuberculosis (Mtb) using the resazurin microtiter assay (REMA) plate method
as an inhibitor of MmpL3 to explore the utility of mycobacterial CRISPR interference for validating target gene essentiality and compound mode of action

生化/生理作用

SQ109 exhibits activity against Helicobacter pylori and the fungi Candida albicans. It might also possess anti-bacterial activity.
SQ109 is an antitubercular developed for the treatment of multidrug-resistant tuberculosis (MDR-TB). SQ109 inhibits the activity of MmpL3, a mycolic acid transporter required for incorporation of mycolic acid into the Mycobacterium tuberculosis cell wall.

基本信息

经验(实验)分子式	C₂₂H₃₈N₂
分子量	330.55
PubChem化学物质编号	329825775
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	oil
颜色	colorless to yellow
储存温度	2-8℃
SMILES string	C/C(CCC=C(C)C)=C\CNCCNC1[C@@H]2C[C@@H]3C[C@H]1C[C@H](C2)C3
InChI	1S/C22H38N2/c1-16(2)5-4-6-17(3)7-8-23-9-10-24-22-20-12-18-11-19(14-20)15-21(22)13-18/h5,7,18-24H,4,6,8-15H2,1-3H3/b17-7+
InChI key	JFIBVDBTCDTBRH-REZTVBANSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable