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位置:首页 > 品牌 > Sigma-Aldrich > t-Boc-N-amido-dPEG®12-acid

t-Boc-N-amido-dPEG®12-acid

品牌
Sigma-Aldrich
货号
QBD10761
包装型号
规格纯度
>95% (HPLC)
参考价格
2333.02 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
t-Boc-N-amido-dPEG®12-acid
BocNH-PEG12-CH2CH2COOH
t-Boc-PEG-acid
t-Boc-N-amido-PEG12-acid
t-Boc-N-amido-PEG12-COOH
产品介绍:

产品说明

特点和优势

t-Boc-N-amido-dPEG12-acid is a monodisperse PEG product that is useful for peptide synthesis. The 40-atoms-long dPEG spacer allows the introduction of a medium-length, hydrophilic spacer onto either end of a peptide chain or on an amino acid side chain. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. The Boc protecting group removes easily with acids such as trifluoroacetic acid (TFA), HF, and trifluoromethane sulfonic acid (TFMSA). Peptide PEGylation imparts water solubility to hydrophobic peptide chains, expands the PEG-peptide conjugates′ hydrodynamic volumes (thus decreasing renal clearance), and protects PEGylated peptides from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the t-Boc-N-amido-dPEGn-acid (n=4, 8, 12, 24, 36) product series.

法律信息

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

基本信息

经验(实验)分子式C32H63NO61
分子量1437.81
MDL编号MFCD13185149

产品性质

测定>95% (HPLC)
形式solid or viscous liquid
reaction suitabilityreaction type: Pegylations
聚合物结构设计shape: linear
functionality: heterobifunctional
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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