TFF-2 human

产品说明

一般描述

Trefoil factor 2 (TFF2), also known as spasmolytic polypeptide, belongs to trefoil factor family (TFF). It is encoded by the gene mapped to human chromosome 21q22.3. The encoded protein consists of two trefoil domains and is primarily expressed along with mucin MUC6 in the gastric epithelium and duodenal Brunner′s glands. Recombinant human TFF2 is a 12.0kDa polypeptide of 106 amino acid residues, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.

生化/生理作用

Trefoil factor family (TFF) members play a vital role in mucus stabilization and stimulation of normal epithelial cell restitution during wound healing via motogenic and antiapoptotic activities. TFF2 is implicated in regulation of gastric mucosal integrity and may hinder tumorigenesis in the stomach. Multiple organ dysfunction syndrome (MODS) patients show elevated expression of TFF2. Overexpression of TFF2 is observed in various gastrointestinal tract disorders, such as gastric ulceration, duodenal ulceration, and Crohn disease of the small intestine. TFF2 stimulates cell migration through activation of protease-activated receptor 4 (PAR4).

外形

Sterile filtered and lyophilized powder.

重悬

Reconstitute in water to a concentration of 0.1-1.0 ug/ul. The solution can then be diluted into other aqueous buffers.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

基本信息

产品性质