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TFF1 human

品牌
Sigma-Aldrich
货号
SRP4893
规格纯度
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
参考价格
4186.79 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
TFF1 human
TFF-1
BCEI
HPS
TFF1
HP1
pS2
产品介绍:

产品说明

一般描述

Trefoil factor 1(TFF1) is a member of trefoil factor family (TFF) and is encoded by the gene mapped to human chromosome 21q22.3. Recombinant human TFF1 is an 8.2kDa polypeptide containing 60 amino acid residues. TFF1 consists of trefoil motif, which is a 40-amino acid domain with three conserved disulfides. TFF1 is expressed and secreted by epithelial cells in the stomach or colon mucous membrane.

生化/生理作用

Trefoil factor family (TFF) members play a vital role in mucus stabilization and stimulation of normal epithelial cell restitution during wound healing via motogenic and antiapoptotic activities. TFF1 prevents anoikis, chemicals or bad-induced apoptosis by decreasing the caspase-3, caspase-6, caspase-8, and caspase-9 activities. TFF1 functions as a tumor suppressor in gastric cancer, whereas it acts as a tumor promoter in mucinous ovarian cancer via regulating the Wnt/β-catenin signaling pathway. Elevated level of TFF1 is observed in patients suffering from Chronic kidney disease (CKD). TFF1 might function as a biomarker for early detection of CKD.

外形

Sterile filtered and lyophilized powder.

重悬

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

基本信息

MDL编号MFCD07370822
NACRESNA.32

产品性质

生物来源human
重组expressed in E. coli
测定≥98% (HPLC)
≥98% (SDS-PAGE)
形式lyophilized
分子量 ~8.2 kDa
包装pkg of 20 μg
储存条件avoid repeated freeze/thaw cycles
杂质 endotoxin, tested
NCBI登记号P04155
运输wet ice
储存温度−20℃
Gene Informationhuman ... TFF1(7031)

Sigma-Aldrich

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