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TNCA

品牌
Sigma-Aldrich
CAS
42438-90-4
货号
SML1711
规格纯度
≥98% (HPLC)
参考价格
772.29 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
42438-90-4
TNCA
(3S)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid
Lycoperodine-1
产品介绍:

产品说明

包装

10, 50 mg in glass bottle

生化/生理作用

TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.

基本信息

经验(实验)分子式C12H12N2O2
分子量216.24
MDL编号MFCD00272641
PubChem化学物质编号329826033
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
旋光性[α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1))
颜色 white to beige
溶解性 1.5 mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed)
储存温度−20℃
SMILES stringO=C(O)[C@H]1NCC2=C(C3=C(N2)C=CC=C3)C1
InChI1S/C12H12N2O2/c15-12(16)10-5-8-7-3-1-2-4-9(7)14-11(8)6-13-10/h1-4,10,13-14H,5-6H2,(H,15,16)/t10-/m0/s1
InChI keyFSNCEEGOMTYXKY-JTQLQIEISA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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