产品说明
一般描述
ULBP1 is ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. In CMV infected cells, ULBP1 interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. Recombinant human ULBP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
外形
0.5 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 30% glycerol and 1 mM DTT.
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | human |
| 重组 | expressed in E. coli |
| 测定 | ≥90% (SDS-PAGE) |
| 形式 | liquid |
| 分子量 | 25 kDa (216 aa, 26-216 aa + His Tag) |
| 包装 | pkg of 100 μg |
| 浓度 | 0.5 mg/mL |
| UniProt登记号 | Q9BZM6 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... ULBP1(80329) |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H319 |
| 预防措施声明 | P264 - P280 - P305 + P351 + P338 - P337 + P313 |
| 危险分类 | Eye Irrit. 2 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
