您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > VLDLR human

VLDLR human

品牌
Sigma-Aldrich
货号
SRP6469
规格纯度
recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE)
参考价格
3487.6 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
VLDLR human
VLDL-R
FLJ35024
very-low-density-lipoprotein receptor
CHRMQ1
VLDLRCH
CARMQ1
产品介绍:

产品说明

一般描述

Very-low-density-lipoprotein receptor (VLDLR) is a 130 kDa type I transmembrane protein in the low density lipoprotein (LDL) receptor family that plays a significant role in lipid metabolism and in nervous system development and function. The VLDL receptor structure is more or less homologous to that LDL receptor, excluding the eightfold repeated ligand binding domain of VLDLR, which is sevenfold in LDLR. The protein sequence of VLDLR is mostly conserved among mammals such as rabbit, human and mouse. The gene is mapped to human chromosome 9p24.2.

生化/生理作用

Very-low-density-lipoprotein receptor (VLDLR) is associated with the metabolism of triglyceride rich lipoproteins (VLDL,β-migrating VLDL and intermediate-density lipoprotein) involving apoprotein-E. It is also one of the receptors of reelin, an extracellular matrix protein which regulates the processes of neuronal migration and synaptic plasticity. It is associated with parental consanguinity and found in secluded communities such as the Hutterites. Deletion in the VLDLR gene results in cerebellar hypoplasia an autosomal recessive syndrome. VLDLR gene is significantly associated with Reelin pathway.

外形

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

产品性质

生物来源human
重组expressed in HEK 293 cells
标签6-His tagged (C-terminus)
测定≥97% (SDS-PAGE)
形式lyophilized
分子量calculated mol wt 86 kDa
observed mol wt 150 kDa by SDS-PAGE (DTT-reduced.)
observed mol wt 180 kDa
包装pkg of 10 μg
pkg of 50 μg
杂质<1 EU/μg endotoxin (LAL test)
UniProt登记号P98155
运输wet ice
储存温度−20℃
Gene Informationhuman ... VLDLR(7436)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品