YZ9

产品名称：

6093-71-6
YZ9
7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylic acid ethyl ester
3-Carbethoxy-7-hydroxycoumarin

产品介绍：

产品说明

包装

10, 50 mg in glass bottle

生化/生理作用

YZ9 is a potent inhibitor of PFKFB3 (6-phosphfructo-2-kinase/fructose-2,6-bisphosphatase) with an IC₅₀ = 183 nM. PFKFB3 is over expressed in many cancers and catalyzes the production of fructose-2,6-bisphosphate, which can potentiate PFK1 activity, enhancing glycolysis in tumor cells. YZ9 dose dependently inhibits proliferation of HeLa cells.
YZ9 is a 5, 6, 7, 8-tetrahydroxy-2-(4-hydroxyphenyl) chromen-4-one (N4A) inhibitor.

基本信息

经验(实验)分子式	C₁₂H₁₀O₅
分子量	234.20
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 5 mg/mL, clear (warmed)
储存温度	−20℃
InChI	1S/C12H10O5/c1-2-16-11(14)9-5-7-3-4-8(13)6-10(7)17-12(9)15/h3-6,13H,2H2,1H3
InChI key	IETDBZQIWIJQJG-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable