Zoniporide hydrochloride hydrate

产品名称：

241800-98-6
Zoniporide hydrochloride hydrate
N-(Aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide hydrochloride hydrate

产品介绍：

产品说明

应用

Zoniporide hydrochloride hydrate has been used for the inhibition of sodium-hydrogen exchanger isoform 1 (NHE-1) in rat models. It has also been used in cytotoxicity assay and to study its effect on lymphocytic choriomeningitis virus multiplication.
Zoniporide hydrochloride hydrate may be used in Na⁺/H⁺-mediated cell signaling studies.

包装

10, 50 mg in glass bottle

生化/生理作用

Zoniporide is a potent and selective inhibitor of Na⁺/H⁺ exchanger isoform 1 (NHE-1). IC₅₀ = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na⁺ update with IC₅₀ of 14 nM.
Zoniporide, a selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE-1) has cardioprotective effects against myocardial injuries and ischemic insults. It inhibits the swelling human platelets and attenuates cardiac contractile dysfunction in rats. Zoniporide might have neurotoxic effects as it causes peripheral sensory axonopathy.

特点和优势

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式	C₁₇H₁₆N₆O · xHCl · yH₂O
分子量	320.35 (anhydrous free base basis)
MDL编号	MFCD04113213
PubChem化学物质编号	329825138
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to tan
溶解性	H₂O: 2 mg/mL, clear (warmed)
创始人	Pfizer
储存温度	2-8℃
SMILES string	O.Cl.NC(=N)NC(=O)c1cnn(-c2cccc3ncccc23)c1C4CC4
InChI	1S/C17H16N6O.ClH.H2O/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);1H;1H2
InChI key	UCIJUEGJEFJRMP-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable