Zotarolimus

产品名称：

221877-54-9
Zotarolimus
ABT-578
(42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin

产品介绍：

产品说明

生化/生理作用

Zotarolimus (ABT-578) is a semi-synthetic rapamycin analog with immunosuppressant and anti-proliferative activity. It binds to the FKBP12 binding protein, which subsequently binds to the mammalian target of rapamycin (mTOR) causing cell cycle arrest in the G1 phase. Zotarolimus was designed to be used for delivery from drug-eluting coronary stents to prevent restenosis.
Zotarolimus is a second generation Drug Eluting Stent (DES).

基本信息

经验(实验)分子式	C₅₂H₇₉N₅O₁₂
分子量	966.21
MDL编号	MFCD09752954

产品性质

测定	≥95% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃
SMILES string	C[C@H](CC[C@@H](C[C@H](OC)/C(C)=C/C=C/C=C/[C@H](C[C@H](C([C@H](OC)[C@@H](/C(C)=C/[C@@H](C)C1=O)O)=O)C)C)O2)[C@]2(O)C(C(N3CCCC[C@H]3C(O[C@H]([C@H](C)C[C@@H]4CC[C@H](N5N=NN=C5)[C@H](OC)C4)C1)=O)=O)=O

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3