产品说明
应用
1-((1-(tert-Butoxycarbonyl)azetidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
920487
920495
920584
ADV638390284
其他说明
Portal:Building PROTAC® Degraders for Targeted Protein Degradation
Crosslinkers for Bioconjugation
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
法律信息
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
基本信息
| 经验(实验)分子式 | C13H19N3O4 |
| 分子量 | 281.31 |
| MDL编号 | MFCD32649299 |
产品性质
| 形式 | powder |
| 质量水平 | 100 |
| 储存温度 | 2-8℃ |
| SMILES string | CC(C)(OC(N1CC(C1)CN2C=C(C(O)=O)C=N2)=O)C CC(C)(OC(N1CC(C1)CN2C=C(C(O)=O)C=N2)=O)C |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
