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位置:首页 > 品牌 > Sigma-Aldrich > 1-((1-(tert-Butoxycarbonyl)azetidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid

1-((1-(tert-Butoxycarbonyl)azetidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid

品牌
Sigma-Aldrich
CAS
2095672-42-5
货号
920576
包装型号
规格纯度
参考价格
2490.2 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
2095672-42-5
1-((1-(tert-Butoxycarbonyl)azetidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid
Rigid linker for PROTAC development
产品介绍:

产品说明

应用

1-((1-(tert-Butoxycarbonyl)azetidin-3-yl)methyl)-1H-pyrazole-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920487
920495
920584
ADV638390284

其他说明

Portal:Building PROTAC® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式C13H19N3O4
分子量281.31
MDL编号MFCD32649299

产品性质

形式powder
质量水平100
储存温度2-8℃
SMILES stringCC(C)(OC(N1CC(C1)CN2C=C(C(O)=O)C=N2)=O)C
CC(C)(OC(N1CC(C1)CN2C=C(C(O)=O)C=N2)=O)C

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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