产品说明
应用
Adefovir is used to treat hepatitis B infections. It is used to study organ-specific toxicity and immune mechanisms of Adefovir treatment.
生化/生理作用
Adefovir is an antiviral acyclic nucleoside phosphonate (ANP) analog that works by blocking reverse transcriptase. It is an inhibitor of duck hepatitis B virus (DHBV) replication that inhibits covalently closed circular DNA (CCC DNA) amplification. Cytotxicity is induced by Human Renal Organic Anion Transporter 1 (hOAT1). Adefovir is an Inhibitor of edema factor (EF)-induced cAMP accumulation and changes in cytokine production in mouse primary macrophages .
其他说明
Keep container tightly closed in a dry and well-ventilated place.
基本信息
| 经验(实验)分子式 | C20H32N5O8P |
| 分子量 | 501.47 |
| MDL编号 | MFCD00869897 |
| PubChem化学物质编号 | 329771057 |
产品性质
| 生物来源 | synthetic |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| 溶解性 | ethanol: 50 mg/mL |
| 作用机制 | enzyme | inhibits |
| 抗生素抗菌谱 | viruses |
| 储存温度 | −20℃ |
| SMILES string | CC(C)(C)C(=O)OCOP(=O)(COCCn1cnc2c(N)ncnc12)OCOC(=O)C(C)(C)C |
| InChI | 1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23) |
| InChI key | WOZSCQDILHKSGG-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H302 + H312 + H332 |
| 预防措施声明 | P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 |
| 危险分类 | Acute Tox. 4 Oral |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
Sigma-Aldrich
m.cnreagent.com
