产品说明
一般描述
NR5A1 (or steroidogenic factor 1) is a nuclear receptor that modulates the transcription of genes involved in the hypothalamic-pituitary-steroidogenic axis. Mutations in NR5A1 have been linked to ovarian insufficiency and congenital adrenal hypoplasia.
Rabbit Anti-NR5A1 antibody recognizes bovine, canine, human, mouse, rat, and pig NR5A1.
免疫原
Synthetic peptide directed towards the middle region of human NR5A1
应用
Rabbit Anti-NR5A1 antibody can be used for western blot (2.0μg/ml) and immunohistochemistry (4-8μg/ml, using paraffin embedded tissues) assays.
生化/生理作用
NR5A1 is an important regulator of steroidogeneisis which is present in human skin and its appendages. It plays a role in regulating p450scc expression with TReP-132 and CBP/p300. The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
序列
Synthetic peptide located within the following region: AVPGAHGPLAGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGP
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 52 kDa |
| species reactivity | human |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI登记号 | NP_004950 |
| UniProt登记号 | Q13285 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... NR5A1(2516) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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