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Anti-NR1I2 (AB1) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
AV39532
规格纯度
IgG fraction of antiserum
参考价格
3311.54 *本价格含增值税费
促销
服务
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  • 增值税票
数量
-+
产品名称:
Anti-NR1I2 (AB1) antibody produced in rabbit
Anti-Nuclear receptor subfamily 1, group I, member 2
产品介绍:

产品说明

一般描述

NR1I2 (PXR) is a transcription factor that belongs to the nuclear receptor family. It associates with the CYP3A4 promoter and the 9-cis retinoic acid receptor RXR. Genetic variations in NR1I2 have been linked to inflammatory bowel disease, lymphoma, and tacrolimus pharmacokinetics.
Rabbit Anti-NR1I2 antibody recognizes pig, canine, human, mouse, rat, bovine, and rabbit NR1I2.

免疫原

Synthetic peptide directed towards the C terminal region of human NR1I2

应用

Rabbit Anti-NR1I2 antibody is suitable for western blot applications at a concentration of 5 μg/ml.

生化/生理作用

NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. NR1I2 contains a zinc finger domain.NR1I2 is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. The gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. The gene product contains a zinc finger domain. Three alternatively spliced transcripts that encode different isoforms have been described, one of which encodes two products through the use of alternative translation initiation codons. Additional transcript variants derived from alternative promoter usage, alternative splicing, and/or alternative polyadenylation exist, but they have not been fully described.

序列

Synthetic peptide located within the following region: PQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGI

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 54 kDa
species reactivitypig, human, dog
浓度0.5 mg - 1 mg/mL
technique(s)western blot: suitable
NCBI登记号NP_071285
UniProt登记号Q9UNW4
运输wet ice
储存温度−20℃
Gene Informationhuman ... NR1I2(8856)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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