产品说明
一般描述
SMAD6 is a transcription factor that belongs to the SMAD family of proteins that regulate cell growth and development. Studies have reported that Smad6 inhibits TGF-β and BMP/Smad1 signaling.
Rabbit Anti-SMAD6 recognizes zebrafish, canine, bovine, human, mouse, rat, and chicken SMAD6.
免疫原
Synthetic peptide directed towards the N terminal region of human SMAD6
应用
Rabbit Anti-SMAD6 can be used for western blot applications at a concentration of 0.5-1.0μg/ml. It can also be used for IHC assays at 4-8μg/ml, using paraffin-embedded tissues.
生化/生理作用
SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.
序列
Synthetic peptide located within the following region: APRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKR
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 53 kDa |
| species reactivity | mouse, rat, dog, pig, human, bovine |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI登记号 | NP_001136333 |
| UniProt登记号 | O43541 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... SMAD6(4091) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
