Congo Red, High Purity-CAS 573-58-0-Calbiochem

产品名称：

573-58-0
Congo Red, High Purity-CAS 573-58-0-Calbiochem
3,3'-[(1,1'-Biphenyl)-4,4'-diylbis(azo)]bis(4-amino-1-naphthalenesulfonic Acid) 2Na

产品介绍：

产品说明

一般描述

An amyloidophylic dye that specifically stains stacked β sheet aggregates. Useful for staining and visual detection of amyloid deposits. Does not bind to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the metabolism of the normal isoform. It is also shown to inhibit Pot1 Binding to Telomeric DNA.
An amyloidophylic dye that specifically stains stacked β sheet aggre-gates. Useful for staining and visual detection of amyloid deposits in nerve tissue. Binds to amyloid fibrils but not to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the normal isoform possibly through overstabilization of the conformation. It is also shown to inhibit Pot1 Binding to Telomeric DNA.

包装

500 mg in Glass bottle

生化/生理作用

Primary Target
An amyloidophylic dye that specifically stains stacked β sheet aggregates
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at room temperature (20°C).

其他说明

Altschuler, S.E., et al. 2012. Biochemistrin press.
Khurana, R., et al. 2001. J. Biol. Chem.276, 22715.
Fezoui, Y., et al. 2000. Amyloid7, 166.
Fezoui, Y., et al. 2000. Nat. Struct. Biol.7, 1095.
Kramport, M., et al. 2000. Chem. Biol.7, 855.
Kuner, P., et al. 2000. J. Biol. Chem.275, 1673.
Caspi, S., et al. 1998. J. Biol. Chem.273, 3484.
Caughey, B., and Race, A.E. 1992. J. Neurochem.59, 768.
Taylor, D.L., et al. 1974. J. Histochem. Cytochem.22, 1105.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₃₂H₂₂N₆O₆S₂ · 2Na
分子量	696.66
MDL编号	MFCD00004028

产品性质

质量水平	100
测定	≥75% dye basis
形式	crystalline solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	rust
溶解性	water: 10 mg/mL ethanol: soluble
运输	ambient
储存温度	15-25℃
InChI	1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2
InChI key	IQFVPQOLBLOTPF-UHFFFAOYSA-L

安全信息

象形图
警示用语：	Danger
危险声明	H350 - H361d
预防措施声明	P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类	Carc. 1B - Repr. 2
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3