产品说明
一般描述
Glutathione S-transferase theta 2 (GSTT2) is an enzyme that in humans is encoded by the GSTT2 gene. GSTT2 is mapped to human chromosome 22q11.2.
生化/生理作用
The θ class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations.
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: α, κ, μ, ω, π, σ, θ and ζ. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
储存及稳定性
The enzyme should be used by the end-user customer within 1 year of receipt.
基本信息
| NACRES | NA.26 |
产品性质
| 质量水平 | 100 |
| 生物来源 | human |
| 重组 | expressed in E. coli |
| 测定 | >95% (SDS-PAGE) |
| 形式 | frozen liquid |
| specific activity | 12.6 units/mg protein (as assayed by the spectrophotometric determination of NADPH oxidation coupled to the glutathione peroxidase activity of GST T2-2 on cumene hydroperoxide (1.5 mM) in the presence of reduced glutathione (1 mM) in 100 mM NaPO4 (pH 7.0) at room temperature.) |
| 分子量 | 25 kDa |
| 浓度 | 1.91 mg/mL |
| 储存温度 | −70℃ |
| Gene Information | human ... GSTT2(2953) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
