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位置:首页 > 品牌 > Sigma-Aldrich > InSolution β-Secretase Inhibitor IV-CAS 797035-11-1-Calbiochem

InSolution β-Secretase Inhibitor IV-CAS 797035-11-1-Calbiochem

品牌
Sigma-Aldrich
CAS
797035-11-1
货号
565794
规格纯度
The InSolution β-Secretase Inhibitor, also referenced under CAS 797035-11-1, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
参考价格
2147.57 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
797035-11-1
InSolution β-Secretase Inhibitor IV-CAS 797035-11-1-Calbiochem
N-(1 S, 2 R)-1-Benzyl-3-(cyclopropylamino)-2-hydroxypropyl)-5-(methyl(methylsulfonyl)amino-N'-((1 R)-1-phenylethyl)isophthalamide
产品介绍:

产品说明

一般描述

A cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). The solid form of this compound (Cat. No. 565788) is also available.

包装

500 μg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
β-Secretase
Target IC50: 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells
Reversible: yes

警告

Toxicity: Irritant (B)

外形

A 10 mM (500 µg/86.4 µL) solution of β-Secretase Inhibitor IV (Cat. No. 565788) in DMSO.

重悬

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. For short term storage, aliquots are stable for up to 3 months at -20°C.

其他说明

Stachel, S.J., et al. 2004. J. Med. Chem.47, 6447.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C31H38N4O5S
分子量578.72
MDL编号MFCD09037559

产品性质

质量水平100
测定≥95% (HPLC)
形式liquid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
运输dry ice
储存温度−70℃
SMILES stringO=C(C1=CC(C(N[C@@H](CC2=CC=CC=C2)[C@H](O)CNC3CC3)=O)=CC(N(S(C)(=O)=O)C)=C1)N[C@H](C)C4=CC=CC=C4

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)188.6 °F - (refers to pure substance)
闪点(C)87 ℃ - (refers to pure substance)

Sigma-Aldrich

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