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Monoclonal Anti-Tumor Necrosis Factor-α antibody produced in hamster

品牌
Sigma-Aldrich
货号
T2824
规格纯度
~2 mg/mL, clone TN3-19.12, purified immunoglobulin, buffered aqueous solution
参考价格
2067.58 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Monoclonal Anti-Tumor Necrosis Factor-α antibody produced in hamster
Anti-TNF-α
产品介绍:

产品说明

一般描述

Monoclonal Anti-Mouse Tumor Necrosis Factor-α (TNF-α) is derived from the TN3-19.12 hybridoma produced by the fusion of mouse myeloma cells (P3X63-Ag8.653) and splenocytes from male Armenian hamster immunized with purified mouse recombinant TNF-α. Tumor necrosis factor (TNF) protein family contains two members: TNF-α (also known as cachectin) and TNF-β (also known as lymphotoxin). These proteins are small molecules with a molecular weight of 17 and 25 kDa respectively and share 30% amino acid homology. TNF-α and -β are secreted from many different cells such as lymphocytes, neutrophils, and macrophages.

特异性

Mouse monoclonal clone TN3-19.12 anti-Tumor Necrosis Factor-α antibody recognizes mouse and rat TNF-α (approx. 17 kDa in its monomer form and 51 kDa in its homotrimer form) and cross-reacts with mouse TNF-β.

免疫原

purified recombinant mouse TNF-α.

应用

Monoclonal Anti-Tumor Necrosis Factor-α antibody produced in hamster has been used in:

  • immunoblotting
  • enzyme-linked immunosorbent assay (ELISA)
  • immunoprecipitation
  • neutralization

包装

200 μL in glass insert

生化/生理作用

TNF-α is a major mediator of inflammatory responses and its over-production results in extensive tissue damage associated with endotoxemia and cachexia. High serum levels of TNF are associated with septic shock, rejection of renal transplants, parasitic infections, and various neoplastic diseases. TNF-α exhibits growth-enhancing activities for normal cells like fibroblasts, T and B cells, activation of endothelial cells, and differentiation of myeloid cells. In neoplastic cells, TNF-α exerts growth inhibitory activities that can be either cytostatic or cytotoxic.

外形

Supplied as a 0.2 μm filtered solution in 0.01 M phosphate buffered saline, pH 7.4.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD01632994
NACRESNA.41

产品性质

质量水平200
生物来源hamster
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆TN3-19.12, monoclonal
形式buffered aqueous solution
species reactivityrat, mouse
包装antibody small pack of 25 μL
浓度~2 mg/mL
technique(s)immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
neutralization: suitable
western blot: 0.25-0.5 μg/mL using recombinant mouse TNF-α
UniProt登记号P16599
运输dry ice
储存温度−20℃
Gene Informationmouse ... Tnf(21926)
rat ... Tnf(24835)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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