<i>N</i>-(4-Bromophenyl)-<i>N</i>-phenylacrylamide

产品名称：

1956368-15-2
N-(4-Bromophenyl)-N-phenylacrylamide
KB05
Electrophilic scout fragment
Scout fragment for targetable cysteine

产品介绍：

产品说明

应用

N-(4-Bromophenyl)-N-phenylacrylamide is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins. This fragment electrophile, or ″scout″ fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC^® molecules for targeted protein degradation as demonstrated by the Cravatt Lab for E3 ligase discovery.

其他说明

Technology Spotlight: Proteomic Ligandability Assessment

Proteome-wide covalent ligand discovery in native biological systems

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式	C₁₅H₁₂BrNO
分子量	302.17

产品性质

质量水平	100
测定	≥95%
形式	(Powder or crystals or solid or chunks)
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3