2-(吡啶-3-羰基氨基)乙基硝酸酯

产品名称：

65141-46-0
Nicorandil
N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide
Sigmart
2-(Pyridine-3-carbonylamino)ethyl nitrate
Ikorel
SG-75
Zynicor
2-Nicotinamidoethyl nitrate
尼可地尔
2-烟酰胺基硝酸乙酯
N-[2-硝氧乙基]-3-吡啶键酰胺
烟浪丁
2-(吡啶-3-羰基氨基)乙基硝酸酯

产品介绍：

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

尼可地尔是一种杂合ATP敏感性K+(KATP)通道开放剂，也是烟酰胺硝酸盐NO供体。尼可地尔能够选择性激活含有SUR2B-和SUR2A-的KATP通道。它可以增强内皮NO合酶的表达，并防止缺血性室性心律失常。尼可地尔通过激活钾离子通道并提供一氧化氮激活鸟苷酸环化酶，引起GMP活化，从而导致动脉和静脉血管舒张。尼可地尔对血管钾离子通道具有选择性，但对心肌收缩和传导没有明显作用。

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式	C₈H₉N₃O₄
分子量	211.17
MDL编号	MFCD00186520
NACRES	NA.24

产品性质

等级	pharmaceutical primary standard
manufacturer/tradename	BP
格式	neat
储存温度	2-8℃
SMILES string	[O-][N+](=O)OCCNC(=O)c1cccnc1
InChI	1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)
InChI key	LBHIOVVIQHSOQN-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H242 - H302
预防措施声明	P210 - P235 - P280 - P301 + P312 - P370 + P378 - P410
危险分类	Acute Tox. 4 Oral - Org. Perox. D
储存分类代码	5.2 - Organic peroxides and self-reacting hazardous materials
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable