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PrEST Antigen XRCC4

品牌
Sigma-Aldrich
货号
APREST71076
规格纯度
Prestige AntigensTM Powered by Atlas Antibodies, buffered aqueous solution
参考价格
4074.61 *本价格含增值税费
促销
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数量
-+
产品名称:
PrEST Antigen XRCC4
产品介绍:

产品说明

一般描述

Recombinant protein fragment of Human XRCC4 with N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G) fusion tag. X-ray repair cross-complementing protein 4 (XRCC4) is also known as DNA repair protein XRCC4. It is mapped to human chromosome locus 5q14.2. It mediates joining of DNA double strand breaks during DNA repair.

应用

Suitable as a blocking agent using corresponding antibodies.

生化/生理作用

X-ray repair cross-complementing protein 4 (XRCC4) interacts with XRCC4-like factor (XLF) and DNA ligase IV in mediating nonhomologous end joining (NHEJ) cascade in DNA repair. A mutation in the XRCC4 is associated with adult-onset progressive encephalocardiomyopathy and ataxia. Patients with polymorphisms in XRCC4 gene are susceptible to schizophrenia. Single nucleotide polymorphisms in XRCC4 associates with high risk for cancer development. Mutations in XRCC4 leads to growth failure resulting in short stature accompanied by facial dysmorphism.(10)

联系

Corresponding Antibody HPA006801.

外形

Solution in 1 M urea-PBS, pH 7.4

制备说明

The protein solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.

法律信息

Prestige Antigens is a trademark of sigma-aldrich Co. LLC

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

质量水平100
重组expressed in E. coli
测定>80% (SDS-PAGE)
形式buffered aqueous solution
分子量predicted mol wt 33 kDa
纯化方式immobilized metal affinity chromatography (IMAC)
浓度≥0.5 mg/mL
免疫原序列KCVSAKEALETDLYKRFILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQTDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEK
基因组数据库 |人类登记号ENSG00000152422
UniProt登记号Q13426
运输wet ice
储存温度−20℃
Gene Informationhuman ... XRCC4(7518)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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