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位置:首页 > 品牌 > Sigma-Aldrich > Anti-Werner′s syndrome helicase (WRN) Antibody, clone 20A11.1

Anti-Werner′s syndrome helicase (WRN) Antibody, clone 20A11.1

品牌
Sigma-Aldrich
货号
MABD34
规格纯度
clone 20A11.1, from mouse
参考价格
6022.61 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Werner′s syndrome helicase (WRN) Antibody, clone 20A11.1
Werner syndrome ATP-dependent helicase, DNA helicase, RecQ-like type 3, RecQ3, Exonuclease WRN, RecQ protein-like 2
产品介绍:

产品说明

一般描述

The Werner’s syndrome helicase (RecQ-like type 3; RecQ3; Exonuclease WRN) is a ubiquitously expressed nuclear protein belonging to the RecQ family. It functions as a helicase and exonuclease enzyme, and plays a crucial role in the formation of DNA replication centers. This protein is also involved in DNA repair and recombination, and may be involved in transcriptional events mediated by RNA polymerase II. It is regulated by phosphorylation and is targeted by the DNA-dependent protein kinase enzyme. Disrupted expression of the gene encoding the Werner’s syndrome helicase protein often results in the production of truncated Werner’s syndrome helicase proteins. Over 50 gene mutations may contribute to this effect—and lead to the development of Werner syndrome, a condition characterized by accelerated aging and early onset of age-related conditions such as cancer, atherosclerosis, and osteoporosis.

免疫原

GST-tagged recombinant protein corresponding to human WRN.

应用

Use Anti-WRN Antibody, clone 20A11.1 (Mouse Monoclonal Antibody) validated in WB to detect WRN clone 20A11.1 also known as Werner syndrome ATP-dependent helicase, RecQ3, Exonuclease WRN.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology

质量

Evaluated by Western Blot in HEK293 cell lysate.

Western Blot Analysis: A 1:2,000 dilution of this antibody detected Werner′s syndrome helicase (WRN) in 10 µg of HEK293 cell lysate.

目标描述

~162 kDa observed

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
HEK293 cell lysate

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified antibody
antibody product typeprimary antibodies
克隆20A11.1, monoclonal
species reactivityhuman
technique(s)western blot: suitable
同位素/亚型IgG1κ
NCBI登记号NP_000544
UniProt登记号Q14191
运输wet ice
Gene Informationhuman ... WRN(7486)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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