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Calpain Inhibitor III-CAS 88191-84-8-Calbiochem

品牌
Sigma-Aldrich
CAS
88191-84-8
货号
208722
规格纯度
The Calpain Inhibitor III, also referenced under CAS 88191-84-8, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
参考价格
2741.8 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
88191-84-8
Calpain Inhibitor III-CAS 88191-84-8-Calbiochem
Carbobenzoxy-valinyl-phenylalaninal, MDL 28170
产品介绍:

产品说明

一般描述

A potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.
A potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM). Reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effect in glutamate-induced toxicity.

包装

25 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Primary Target
calpain 1, calpain 2
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

序列

Z-Val-Phe-CHO

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Chatterjee, S., et al. 1998. J. Med. Chem.41, 2663.
Rami, A., et al. 1997. Neurosci. Res. 27, 93.
Yamazaki, T., et al. 1997. Biochemistry36, 8377.
Klafki, H., et al. 1996. J. Biol. Chem.271, 28655.
Chard, P.S., et al. 1995. Neuroscience 65, 1099.
Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C22H26N2O4
分子量382.45
MDL编号MFCD00798796
NACRESNA.77

产品性质

质量水平100
测定≥95% (HPLC)
形式lyophilized solid
效能8 nM IC50
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
颜色 white
溶解性DMSO: 20 mg/mL (Use only anhydrous DMSO.)
运输ambient
储存温度2-8℃
InChI1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20-/m0/s1
InChI keyNGBKFLTYGSREKK-PMACEKPBSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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