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位置:首页 > 品牌 > Sigma-Aldrich > 3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine

3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine

品牌
Sigma-Aldrich
CAS
952143-02-1
货号
906298
包装型号
规格纯度
参考价格
1518.97 *本价格含增值税费
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数量
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产品名称:
952143-02-1
3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine
Suzuki-Miyaura-compatible multifunctional photo probe building block
Trifluoromethyl diazirine aryl bromide
Probe building block for photoaffinity labeling
产品介绍:

产品说明

应用

3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine is a Suzuki-Miyaura (S−M)-compatible building block tailored for the design of photoaffinity probes (PAPs). Photoaffinity labeling (PAL) is of growing interest in chemical biology and drug discovery research for use in protein profiling; covalent inhibitors; protein-protein interactions and complexes; and target engagement, identification, or validation studies. Diazirines are desirable photoactivable groups for chemical probes; however, their installation is not always straightforward. In response, diazirine-tolerant S-M coupling conditions were developed by Ichiishi, et al, using 3-(4-bromophenyl)-3-(trifluoromethyl)-3H-diazirine and shown to be efficient and scalable with minimal perturbation of the diazirine.

其他说明

Reducing Limitation in Probe Design: The Development of a Diazirine-Compatible Suzuki-Miyaura Cross Coupling Reaction

基本信息

经验(实验)分子式C8H4BrF3N2
分子量265.03

产品性质

测定≥95%
形式liquid
reaction suitabilityreagent type: cross-linking reagent
储存温度2-8℃
SMILES stringBrC1=CC=C(C2(N=N2)C(F)(F)F)C=C1

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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