3-(7-(<i>tert</i>-Butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-<i>a</i>]pyrazin-3-yl)propanoic acid

产品名称：

3-(7-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)propanoic acid
Rigid linker for PROTAC development

产品介绍：

产品说明

应用

3-(7-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)propanoic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920568
920657
ENAH38A2CCD6
AC5372910424

其他说明

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式	C₁₄H₂₁N₃O₄
分子量	295.33

产品性质

形式	powder
质量水平	100
储存温度	2-8℃
SMILES string	CC(C)(OC(N1CCN2C(CCC(O)=O)=CN=C2C1)=O)C CC(C)(OC(N1CCN2C(CCC(O)=O)=CN=C2C1)=O)C

3-(7-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)propanoic acid