产品说明
免疫原
Immunogen Sequence: GI # 32483361, sequence 307-388
Recombinant apoptotic protease activating factor isoform d
应用
Anti-APAF1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生化/生理作用
Apoptotic protease activating factor 1 is a human homolog of C. elegans CED-4 gene and is a key regulator gene of apoptosis. It acts as a central component of the intrinsic pathway of apoptosis. Loss of APAF-1 expression is involved with chemorefractory malignant melanoma and neuronal cell differentiation. Over expression of this gene is related to an undifferentiated state in the testicular germ cell tumor (TGCT) pathway and is involved in carcinogenesis of germ cell tumors. APAF-1, when bound to cytochrome c, may trigger the activation of caspase-3 leading to apoptosis.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide.
基本信息
| MDL编号 | MFCD02095846 |
| NACRES | NA.41 |
产品性质
| 生物来源 | chicken |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human, mouse |
| manufacturer/tradename | Genway 15-288-21169 |
| technique(s) | western blot: suitable |
| NCBI登记号 | NP_863658.1 |
| UniProt登记号 | O14727 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... APAF1(317) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
Sigma-Aldrich
m.cnreagent.com
