产品说明
一般描述
Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. BMAL1 is the only component of the mammalian circadian clock whose sole deletion in a mouse model generates arrhythmicity. In addition to defects in the clock, these BMAL1 null-mice also have reproductive problems are small in stature, age quickly and have progressive arthropathy that results in having less overall locomotor activity than wild type mice. Recent phenotyping data suggests that BMAL1 and its partner Clock also play a role in regulation of glucose homeostasis and metabolism. Finally, BMAL1, NPAS2, and PER2 have been associated with seasonal affective disorder in humans. BMAL1 transcription is circadian and reciprocally regulated by NR1D1 (Rev-erb-alpha) and RORA, which establishes a second interlocking loop in the mammalian circadian clock.
特异性
Reactivity with other species has not been tested.
Cat. # AB2204 will recognize the C-terminus of BMAL1.
免疫原
Epitope: C-Terminus
Recombinant Protein
应用
Research Sub Category
Circadian Rhythm & Sleep
Anti-BMAL1 Antibody is an antibody against BMAL1 for use in WB.
Research Category
Neuroscience
质量
Routinely tested on C2C12 tissue lysate
Lot Specific Tested Application 1: Western Blot
目标描述
~69 kDa
外形
Serum with 0.05% NaN3
储存及稳定性
Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
分析说明
Control
C2C12 Tissue lysate
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
产品性质
质量水平 | 100 |
生物来源 | guinea pig |
抗体形式 | serum |
antibody product type | primary antibodies |
克隆 | polyclonal |
species reactivity | mouse, rat, human |
technique(s) | western blot: suitable |
NCBI登记号 | NP_031515 |
UniProt登记号 | O00327 |
运输 | wet ice |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 1 |
Sigma-Aldrich