您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > Anti-R-Spondin 2 Antibody, clone 14C7.1

Anti-R-Spondin 2 Antibody, clone 14C7.1

品牌
Sigma-Aldrich
货号
MABS1709
规格纯度
clone 14C7.1, from mouse
参考价格
5016.79 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-R-Spondin 2 Antibody, clone 14C7.1
Roof plate-specific spondin-2, hRspo2
产品介绍:

产品说明

一般描述

R-spondin-2 (UniProt: Q6UXX9; also known as Roof plate-specific spondin-2, hRspo2) is encoded by the RSPO2 (also known as UNQ9384/PRO34209) gene (Gene ID: 340419) in human. R-spondin-2 is a secreted protein that acts as an activator of the canonical Wnt signaling pathway by acting as a ligand for LGR receptors. Upon binding to LGR receptors (LGR4, LGR5 or LGR6) these receptors associate with phosphorylated LRP6 and frizzled receptors, which are activated by extracellular Wnt receptors. These events trigger the canonical Wnt signaling pathway to increase expression of target genes. R-spondin-2 also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling pathway by acting as an inhibitor of ZNRF3, an E3 ubiquitin-protein ligase that serves as an important regulator of the Wnt signaling pathway. In humans, R-Spondin 2 is expressed in organs of endodermal origin in adults, including intestine and lungs and is reported to downregulated in tumors involving these organs. In the embryonic mice it is abundantly expressed in the hippocampus and in developing bones.

特异性

Clone 14C7.1 specifically detects human R-spondin-2. It targets an epitope within 74 amino acids from the C-terminal end.

免疫原

GST/His-tagged recombinant fragment corresponding to 74 amino acids from the C-terminal end of human R-Spondin 2.

应用

Anti-R-Spondin 2, clone 14C7.1, Cat. No. MABS1709, is a mouse monoclonal antibody that specifically targets R-Spondin 2 (RSPO2) and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
Research Category
Signaling
Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected RSPO2 in human pancreas, human kidney, and human bone marrow tissue.

质量

Evaluated by Western Blotting in human recombinant R-spondin 2 protein.

Western Blotting Analysis: 0.02 µg/mL of this antibody detected 0.05 µg of human recombinant R-spondin 2 protein.

目标描述

~35 kDa observed; 28.31 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

外形

Protein G purified
Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Format: Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702

产品性质

质量水平100
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆14C7.1, monoclonal
species reactivityhuman
包装antibody small pack of 25 μg
technique(s)immunohistochemistry: suitable (paraffin)
western blot: suitable
同位素/亚型IgG2bκ
NCBI登记号NP_848660
UniProt登记号Q6UXX9
运输ambient
Gene Informationhuman ... RSPO2(340419)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品