Autophagy Inducer, STF-62247-CAS 315702-99-9-Calbiochem

品牌

Sigma-Aldrich

CAS

315702-99-9

货号

189497

包装型号

10 MG, A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL-deficient, but not VHL-expressing, renal carcinoma cells both in vitro and in mice in vivo.

规格纯度

A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL-deficient, but not VHL-expressing, renal carcinoma cells both in vitro and in mice in vivo.

参考价格

1123.01 元 *本价格含增值税费

促销

数量

产品名称：

315702-99-9
Autophagy Inducer, STF-62247-CAS 315702-99-9-Calbiochem
N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine

产品介绍：

产品说明

一般描述

A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC₅₀ = 0.625 and 16 µM in RCC4 and RCC4/VHL killing, respectively) and in mice in vivo (>90% 786-O tumor growth suppression; 8 mg/kg via daily i.p.). Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.

包装

10 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Toxic (F)

其他说明

Turcotte, S., et al. 2008. Cancer Cell14, 90.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₅H₁₃N₃S
分子量	267.35
MDL编号	MFCD01121974

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	beige
溶解性	DMSO: 50 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

危险声明	H413
预防措施声明	P273 - P501
危险分类	Aquatic Chronic 4
储存分类代码	11 - Combustible Solids
WGK	WGK 2