C5 Lenalidomide-C6-PEG1-C3-PEG1-Butyl NH2 hydrochloride

产品名称：

C5 Lenalidomide-C₆-PEG₁-C₃-PEG₁-Butyl NH₂ hydrochloride
6-((5-((6-Aminohexyl)oxy)pentyl)oxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)hexanamide hydrochloride
Protein degrader building block for PROTAC research
Crosslinker-E3 Ligase ligand conjugate
C5 Lenalidomide conjugate
Template for synthesis of targeted protein degrader

产品介绍：

产品说明

应用

Protein degrader building block C5 Lenalidomide-C₆-PEG₁-C₃-PEG₁-Butyl NH₂ hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand with alternative exit vector, a linker with both hydrophobic and hydrophilic moieties, and a pendant amine for reactivity with an acid on the target warhead. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

其他说明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式	C₃₀H₄₆N₄O₆ · xHCl
分子量	558.71 (free base basis)

产品性质

质量水平	100
测定	≥95%
形式	powder or crystals
储存温度	2-8℃
SMILES string	O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(CCCCCOCCCCCOCCCCCCN)=O)=CC=C31.Cl O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(CCCCCOCCCCCOCCCCCCN)=O)=CC=C31.Cl

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable