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位置:首页 > 品牌 > Sigma-Aldrich > C5 Lenalidomide-pyrimidine-piperazine-PEG1-NH2 hydrochloride

C5 Lenalidomide-pyrimidine-piperazine-PEG1-NH2 hydrochloride

品牌
Sigma-Aldrich
货号
921300
包装型号
规格纯度
≥95%
参考价格
5850.62 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
C5 Lenalidomide-pyrimidine-piperazine-PEG1-NH2 hydrochloride
5-(4-(2-(2-Aminoethoxy)ethyl)piperazin-1-yl)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)pyrimidine-2-carboxamide hydrochloride
Protein degrader building block for PROTAC research
Crosslinker-E3 Ligase ligand conjugate
Template for synthesis of targeted protein degrader
产品介绍:

产品说明

应用

Protein degrader builiding block C5 Lenalidomide-pyrimidine-piperazine-PEG1-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand with alternative exit vector, a linker with added rigidity, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

其他说明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式C26H32N8O5 · xHCl
分子量536.58 (free base basis)

产品性质

质量水平100
测定≥95%
形式 (Powder or crystals or flakes or chunks)
储存温度2-8℃
SMILES stringO=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(C4=NC=C(N5CCN(CCOCCN)CC5)C=N4)=O)=CC=C31.Cl
O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(C4=NC=C(N5CCN(CCOCCN)CC5)C=N4)=O)=CC=C31.Cl

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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