Cardiotoxicity Ligand Set

产品说明

一般描述

A set of 52 compounds are arranged in 96-well format, one compound per well (250 μl at 10 mM in DMSO)

应用

Cardiotoxicity Ligand Set has been used in the cumulative drug dosage studies on engineered human induced pluripotent stem cell-derived cardiomyocyte (hiPS-CM) tissues.

生化/生理作用

Cardiotoxicity is an important cause for concern in drug development and appears to cut across therapeutic indications and drug classes. Several drugs have been removed from the market recently because of prolonging the QT interval or causing Torsades de Pointes (TdP).

The Cardiotoxicity Ligand Set features a wide variety of drugs including anti-arrhythmics, antihistamines, antibiotics, anticonvulsants, antidepressants and antipsychotics that are known to have cardiotoxic side-effects.

特点和优势

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
SDFile provided to construct a database containing:

• Structure
• Primary Name
• Secondary Name
• Pharmacological Activity
• Product Number
• Rack Position

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H302 - H350 - H360FD - H362 - H411
预防措施声明	P202 - P263 - P264 - P273 - P301 + P312 - P308 + P313
危险分类	Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 1A - Lact. - Repr. 1B
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable