Caspase Modulator II, 1541B-Calbiochem

产品说明

一般描述

A cell-permeable, of 8-Hydroxy 1541 (Cat. No. 529662) analog that is shown to selectively activate procaspase-3 (EC₅₀ = 1.3 µM), but not procaspase-6. Both 1541 and 1541B are shown to effectively induce apoptosis in various cancer cell lines with comparable potencies, indicating that caspase-3 activation alone is as effective as simultaneous activations of caspase-3/-6 in cell death induction of the cells tested. 1541B is expected to inhibit the activity of mature/active caspase-3 and exhibit reduced procaspase-3 activation at high concentrations.
A cell-permeable, of 8-Hydroxy analog 1541 (Cat. No. 529662) that is shown to selectively activate procaspase-3 (EC₅₀ = 1.3 µM), but not procaspase-6. Both 1541 and 1541B are shown to effectively induce apoptosis in various cancer cell lines with comparable potencies, indicating that caspase-3 activation alone is as effective in cell death induction as simultaneous activations of caspase-3/-6 among cells tested. 1541B is expected to inhibit the activity of mature/active caspase-3 and exhibit reduced procaspase-3 activation at high concentrations.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Wolan, D.W., et al. 2009. Science326, 853.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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