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DNA Base Excision Repair Pathway Inhibitor-CAS 6960-45-8-Calbiochem

品牌
Sigma-Aldrich
CAS
6960-45-8
货号
262015
规格纯度
The DNA Base Excision Repair Pathway Inhibitor, also referenced under CAS 6960-45-8, controls the biological activity of APE1 (human apurinic/apyrimidinic endonuclease.
参考价格
1709.38 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
6960-45-8
DNA Base Excision Repair Pathway Inhibitor-CAS 6960-45-8-Calbiochem
7-Nitroindole-2-carboxylic acid, CRT0044876
产品介绍:

产品说明

一般描述

A cell-permeable, potent, specific, and nontoxic inhibitor of the DNA repair enzyme, APE1 (human apurinic/apyrimidinic endonuclease; IC50 = ~3 µM). Shown to target the APE1 active site and inhibit its 3′-phosphodiesterase and 3′-phosphatase activities. Exhibits minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentration as high as 100 µM. Also shown to potentiate the cytotoxicity of several DNA damaging agents, such as MMS, temozolomide, Zeocin, and H2O2 in HeLa, HT1080, and MDA-MB-231 cells.
A cell-permeable, potent, specific, and nontoxic inhibitor of the DNA repair enzyme, APE1 (human apurinic/apyrimidinic endonuclease; IC50 ~3 µM). Shown to target the APE1 active site and inhibit its 3′-phosphodiesterase and 3′-phosphatase activities. Exhibits minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentration as high as 100 µM. Also shown to potentiate the cytotoxicity of several DNA damaging agents, such as MMS, temozolomide, Zeocin, and H2O2 in HeLa, HT1080, and MDA-MB-231 cells.

包装

25 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
APE 1
Product does not compete with ATP.
Reversible: no
Target IC50: ~3 µM against APE1 (human apurinic/apyrimidinic endonuclease

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Madhusudan, S., et al. 2005. Nucl. Acids Res.33, 4711.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C9H6N2O4
分子量206.15
MDL编号MFCD00044720

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 tan
溶解性DMSO: 5 mg/mL
运输ambient
储存温度2-8℃
InChI1S/C9H6N2O4/c12-9(13)6-4-5-2-1-3-7(11(14)15)8(5)10-6/h1-4,10H,(H,12,13)/p-1
InChI keyBIUCOFQROHIAEO-UHFFFAOYSA-M

安全信息

象形图GHS08
警示用语:Danger
危险声明H319 - H334
预防措施声明P261 - P264 - P280 - P284 - P304 + P340 + P312 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Resp. Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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