DUB Inhibitor V, PR-619-Calbiochem

品牌

Sigma-Aldrich

货号

662141

包装型号

25 MG, The DUB Inhibitor V, PR-619 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

规格纯度

The DUB Inhibitor V, PR-619 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

参考价格

2340.22 元 *本价格含增值税费

促销

数量

产品名称：

DUB Inhibitor V, PR-619-Calbiochem
UCH-L3 Inhibitor II, UCH-L5/UCH37 Inhibitor III, USP5 Inhibitor II, USP7 Inhibitor I, USP9X Inhibitor II, USP14 Inhibitor IV, USP14 Inhibitor IV, USP47 Inhibitor I, 2,6-Diaminopyridine-3,5-bis(thiocyanate), 3,5-Dithiocyanatopyridine-2,6-diamine, PR619, UC
2,6-Diaminopyridine-3,5-bis(thiocyanate), 3,5-Dithiocyanatopyridine-2,6-diamine, PR619, UCH-L1 Inhibitor IV, UCH-L3 Inhibitor II, UCH-L5/UCH37 Inhibitor III, USP5 Inhibitor II, USP7 Inhibitor I, USP9X Inhibitor II, USP14 Inhibitor IV, USP14 Inhibitor IV, USP47 Inhibitor I

产品介绍：

产品说明

一般描述

A cell-permeable pyridinamine class broad-spectrum DUB inhibitor whose known targets include ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. Both PR-619 and P22077 (Cat. No. 662142) are shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150 µM; 0.5 to 20 h), however P22077 exposure results in mainly enrichment of K⁴⁸-linked, while PR619 treatment results in upregulation of both K⁴⁸- and K⁶³-linked polyUb chains.

包装

25 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₇H₅N₅S₂
分子量	223.28

产品性质

质量水平	100
测定	≥99% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	beige
溶解性	DMSO: 50 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3