E7820-C<sub>3</sub>-NH<sub>2</sub> hydrochloride

产品名称：

E7820-C₃-NH₂ hydrochloride
DCAF15 protein degrader building block
Crosslinker-E3 Ligase ligand conjugate
N-(3-Aminopropyl)-3-(N-(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl)benzamide hydrochloride

产品介绍：

产品说明

应用

Protein degrader building block E7820-C₃-NH₂ hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC^® (proteolysis-targeting chimeras) research. This conjugate contains a DCAF15-recruiting ligand E7820 (SML2950), an alkyl linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Protein Degrader Building Blocks

Technology Spotlight: DCAF15 Degrader Building Blocks for Targeted Protein Degradation

其他说明

In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式	C₂₀H₂₁N₅O₃S · xHCl
分子量	411.48 (free base basis)

产品性质

质量水平	100
储存温度	2-8℃

E7820-C3-NH2 hydrochloride

E7820-C₃-NH₂ hydrochloride