您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > eIF4E/eIF4G Interaction Inhibitor, 4EGI-1-CAS 315706-13-9-Calbiochem

eIF4E/eIF4G Interaction Inhibitor, 4EGI-1-CAS 315706-13-9-Calbiochem

品牌
Sigma-Aldrich
CAS
315706-13-9
货号
324517
规格纯度
The eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, also referenced under CAS 315706-13-9, controls the biological activity of eIF4E/eIF4G interaction. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation application
参考价格
3543.57 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
315706-13-9
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1-CAS 315706-13-9-Calbiochem
2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I
产品介绍:

产品说明

一般描述

A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC50 ~25 µM).
A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 h), leading to apoptotic cell death after prolonged exposure (24 h, IC50 = ~ 25 µM). Also available as a 25 mM solution in DMSO (Cat. No. 324519).

包装

10 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Moerke, N. J., et al. 2007. Cell128, 257.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C18H12Cl2N4O4S
分子量451.28

产品性质

质量水平100
测定≥98% (sum of two isomers, HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 yellow
溶解性DMSO: 100 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)677.1 °F - (calculated)
闪点(C)358.4 ℃ - (calculated)

Sigma-Aldrich

推荐产品