<I>N</I>-α-(9-Fluorenylmethyloxycarbonyl)-4-(trifluoromethyldiazirin)-<SC>L</SC>-phenylalanine

产品名称：

133342-64-0
Fmoc-L-Photo-Phe-OH
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)propanoic acid
Fmoc-Tdf-OH
Photo-crosslinking amino acid
Photoprobe building block
N-α-(9-Fluorenylmethyloxycarbonyl)-4-(trifluoromethyldiazirin)-L-phenylalanine
Diazirine amino acid
Photo-Phe

产品介绍：

产品说明

应用

Fmoc-L-Photo-Phe-OH is a diazirine-containing, Fmoc-protected phenylalanine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (∼360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907340.

其他说明

Covalent modifier-type aggregation inhibitor of amyloid-β based on a cyclo-KLVFF motif

Mode of Action of cGMP-dependent Protein Kinase-specific Inhibitors Probed by Photoaffinity Cross-linking Mass Spectrometry

Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation

Simple and Versatile Method for Tagging Phenyldiazirine Photophores

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

基本信息

经验(实验)分子式	C₂₆H₂₀F₃N₃O₄
分子量	495.45
MDL编号	MFCD30187628

产品性质

测定	≥95%
形式	powder
reaction suitability	reaction type: Fmoc solid-phase peptide synthesis
application(s)	peptide synthesis
官能团	Fmoc
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3